Prophylactic Bilateral Salpingectomy as a Prevention Strategy in Women at High-Risk of Ovarian Cancer: A Mini-Review
نویسندگان
چکیده
منابع مشابه
Prophylactic Bilateral Salpingectomy as a Prevention Strategy in Women at High-Risk of Ovarian Cancer: A Mini-Review
Risk-reducing bilateral salpingo-oophorectomy is a proven strategy to reduce the risk of serous ovarian cancer associated with germline BRCA mutations. It is most effective when performed before natural menopause, but it will render a woman prematurely menopausal. The tubal hypothesis of serous ovarian cancer brings with it the possibility of the alternative surgical approach in younger women c...
متن کاملSalpingectomy as a potential ovarian cancer risk-reducing procedure.
Accumulated evidence over the past 10 years has strongly indicated that the fallopian tube is the site of origin for many high-grade serous carcinomas (1), which represent 50% to 60% of all epithelial ovarian cancers. This multi-origin model of ovarian cancer development has important implications for prevention of ovarian cancer: if some or all high-grade serous tumors develop in the fallopian...
متن کاملSalpingectomy as a means to reduce ovarian cancer risk.
Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the m...
متن کاملThe Role of Bilateral Prophylactic Mastectomy (BPMX) in Women at High Risk of Breast Cancer
Women at high personal risk of breast cancer can be identified from family history using Claus data or from genetic testing for BRCAI and BRCA2 mutations. Women at such risk may be offered surveillance, entry into a chemoprevention trial such as IBIS, or bilateral prophylactic mastectomy (BPMX). Recent published data on the use of Tamoxifen as a chemopreventative agent found reduction of risk i...
متن کاملCosts and benefits of opportunistic salpingectomy as an ovarian cancer prevention strategy.
OBJECTIVE To conduct a cost-effectiveness analysis of opportunistic salpingectomy (elective salpingectomy at hysterectomy or instead of tubal ligation). METHODS A Markov Monte Carlo simulation model estimated the costs and benefits of opportunistic salpingectomy in a hypothetical cohort of women undergoing hysterectomy for benign gynecologic conditions or surgical sterilization. The primary o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2014
ISSN: 2234-943X
DOI: 10.3389/fonc.2014.00021